A new non-invasive method to predict endometrial receptivity using endometrial liquid biopsy
The endometrium is a hormonally regulated organ that is non-adhesive to embryos throughout most of the menstrual cycle in humans. Endometrial receptivity refers to a limited period in which the endometrial tissue is able to receive the embryo to start a pregnancy. The diagnosis of endometrial receptivity is being used as a clinical test to manage endometrial factor in patients with implantation failure.
Until now, this procedure required the collection of an endometrial biopsy, an invasive and painful technique that delays the personalized embryo transfer (pET) until the next cycle. The scientific study presented at the 73rd ASRM Scientific Congress, which is taking place over the course of several days in San Antonio (TX, USA) considers the use of endometrial fluid instead of using a traditional endometrial biopsy.
This new kind of sample consists of an endometrial liquid biopsy collected by a non-invasive method avoiding pain and discomfort to the patient.
This technique will allow the development of a new, non-invasive approach, based on the analysis of the transcriptomic signature in the endometrial fluid (EF).
This methology, applied to niERA (Non-invasive ERA test) wil have some specific benefits:
Once the new technique is mastered by each clinician, the endometrial liquid biopsy will be ready to use in the niERA test (non-invasive ERA) and EMMA (Endometrial microbiome metagenomic analysis).
*Moreno et al., AM J Obstet Gynecol, 2016; 215:684-703.
If you are part of one of the clinics we have invited to join this pilot transition, you may have some questions.
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