Endometrial liquid biopsy

A new non-invasive method to predict endometrial receptivity using endometrial liquid biopsy

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  • The usual approach to analyze endometrial receptivity and to personalize embryo transfer has been traditional endometrial biopsy.
  • Traditional biopsy is slightly painful and invasive for patients, requiring a period of healing before attempting embryo transfer.
  • In a recent scientific study presented by Igenomix, researchers have found that testing of the endometrial fluid can give the same information as a traditional biopsy.

More info


The endometrium is a hormonally regulated organ that is non-adhesive to embryos throughout most of the menstrual cycle in humans. Endometrial receptivity refers to a limited period in which the endometrial tissue is able to receive the embryo to start a pregnancy. The diagnosis of endometrial receptivity is being used as a clinical test to manage endometrial factor in patients with implantation failure.

Until now, this procedure required the collection of an endometrial biopsy, an invasive and painful technique that delays the personalized embryo transfer (pET) until the next cycle. The scientific study presented at the 73rd ASRM Scientific Congress, which is taking place over the course of several days in San Antonio (TX, USA) considers the use of endometrial fluid instead of using a traditional endometrial biopsy.

This new kind of sample consists of an endometrial liquid biopsy collected by a non-invasive method avoiding pain and discomfort to the patient.

This technique will allow the development of a new, non-invasive approach, based on the analysis of the transcriptomic signature in the endometrial fluid (EF).


  • With this technique both endometrial cells and bacterial cells can be analyzed to predict endometrial receptivity and endometrial microbiome.

This methology, applied to niERA (Non-invasive ERA test) wil have some specific benefits:

  • Patients will benefit from this unique biopsy by saving time and resources, reducing emotional and physical discomfort.
  • In the near future, it is possible that embryo transfer could be performed in the same cycle as the endometrial fluid sample was retrieved. 

Clinical application

Once the new technique is mastered by each clinician, the endometrial liquid biopsy will be ready to use in the niERA test (non-invasive ERA) and EMMA (Endometrial microbiome metagenomic analysis).

  • Our ERA test, now performed on endometrial fluid.
  • The same information in a gentle and non-invasive experience for your patients.
  • IGENOMIX continued focus on the endometrium has led to a new ERA test.
  • Sample collection is easy and quick, just a few microliters of endometrial fluid allows us to perform the test.
  • One step further on endometrial status analysis.
  • EMMA studies the endometrial microbiome profile and adds information of the patient's reproductive prognosis.
  • 50% of infertile women had a low abundance of Lactobacillus in the uterus, which is linked to a poor reproductive outcome according to pilot study.*

*Moreno et al., AM J Obstet Gynecol, 2016; 215:684-703.

How to perform an Endometrial liquid biopsy

How to start

If you are part of one of the clinics we have invited to join this pilot transition, you may have some questions.

Our results

Our experts are professional, reliable and approachable and are available to help guide both professionals and patients throughout the entire process. We are proud to deliver high quality results for every test, every day.


to develop
this methodology


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of experience


scientific publications
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